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Phosphorothioate Bonds Modifications
Phosphorothioate Bond
The phosphorothioate (PS) bond substitutes a sulfur atom for a non-bridging oxygen in the phosphate backbone of an oligo. This modification renders the internucleotide linkage resistant to nuclease degradation. Phosphorothioates can be introduced at either the 5'- or 3'-end of the oligo to inhibit exonuclease degradation. In antisense oligonucleotides, phosphorothioates are also introduced internally to limit attack by endonucleases.
Phosphorothioate Bond
 
Phosphorothioate Bond Entry
Phosphorothioated DNA bases _* i.e. A*
Phosphorothioated RNA bases r_* i.e. rA*
Phosphorothioated 2' O-methyl bases m_* i.e. mA*
Phosphorothioated LNA bases +_* i.e. +A*
Pricing Details (price per bond)
Product Pricing Order
100 nmole DNA oligo $3.5 USD Add to Order
250 nmole DNA oligo $3.5 USD Add to Order
1 µmole DNA oligo $5 USD Add to Order
5 µmole DNA oligo $20 USD Add to Order
10 µmole DNA oligo $30 USD Add to Order
 
 
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